Tumour Necrosis Factor Gene Polymorphism and Disease Prevalence
نویسندگان
چکیده
منابع مشابه
Tumour necrosis factor-alpha gene promoter polymorphism in chronic obstructive pulmonary disease.
Tumour necrosis factor(TNF)-alpha levels are elevated in airways of patients with chronic obstructive pulmonary disease (COPD) and may contribute to its pathogenesis. A guanine to adenine substitution at position -308 of the TNF-alpha gene promoter (TNF1/2) has been associated with chronic bronchitis of various aetiologies in a Taiwanese population. The authors performed a study investigating a...
متن کاملTumour necrosis factor and Crohn's disease.
The production of several pro-inflammatory cytokines is increased in inflammatory bowel diseases (IBD). Experimental models of IBD have further defined the importance of specific cytokines for the induction of mucosal inflammation, by using specific neutralising antibodies, or by silencing cytokine genes in mice by using homologous recombination (knockout mice).' 2 Several therapeutic strategie...
متن کاملAssociation between polymorphism of tumour necrosis factor a-308 gene promoter and asthma: a meta-analysis
Background: Asthma is a complex polygenic disease in which gene–environment interactions are important. The gene encoding tumour necrosis factor alpha (TNFa) is one of several candidate loci for asthma pathogenesis and is highly polymorphic. A number of studies have investigated the polymorphism of TNFa-308 gene promoter (substitution GRA, designated as TNF1 and TNF2) in relation to asthma susc...
متن کاملAssociation between polymorphism of tumour necrosis factor alpha-308 gene promoter and asthma: a meta-analysis.
BACKGROUND Asthma is a complex polygenic disease in which gene-environment interactions are important. The gene encoding tumour necrosis factor alpha (TNFalpha) is one of several candidate loci for asthma pathogenesis and is highly polymorphic. A number of studies have investigated the polymorphism of TNFalpha-308 gene promoter (substitution G-->A, designated as TNF1 and TNF2) in relation to as...
متن کاملLack of association between adult asthma and the tumour necrosis factor alpha-308 polymorphism gene.
Tumour necrosis factor (TNF)alpha is a cytokine endowed with potent inflammatory properties that may contribute to airway inflammation in asthma. It has previously been shown that the single base pair polymorphism-308 (G to A substitution) in the promoter of TNFalpha gene results in enhanced cytokine secretion. Whether this polymorphism is associated with the presence of phenotypic expression o...
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ژورنال
عنوان ژورنال: Scandinavian Journal of Immunology
سال: 2011
ISSN: 0300-9475
DOI: 10.1111/j.1365-3083.2011.02602.x